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ANDY LIWANG LABORATORY

SELECTED PUBLICATIONS

Click here for a longer list of publications on Google Scholar (which does not include papers when Andy's surname was Wang)

Conformational switching by KaiA regulates KaiB-KaiC interactions in the cyanobacterial circadian clock
Athira Chandradasan et al
Submitted

Too cold to tick: circadian clock failure at physiologically permissive temperatures
Katherina Martinez & Andy LiWang
Submitted

Mechanism and reconstitution of circadian transcription in cyanobacteria

Nat. Struct. Mol. Biol. (2026) 33: 275-281

Publications: Publications

Reconstitution of circadian clock in synthetic cells reveals principles of timekeeping

Nat Commun (2025) 16, 6686

The Cyanobacterial Circadian Clock

NPJ Biol. Timing Sleep (2025) 2: 26

Unveiling the Cold Reality of Metamorphic proteins

PNAS (2025) 122: e2422725122

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Temperature-dependent fold-switching mechanism of the circadian clock protein KaiB

PNAS (2024) 121: e2412327121

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The inner workings of an ancient biological clock

TIBS (2024) 49: 236-246

Synchronization of the Circadian Clock to the Environment Tracked in Real Time

PNAS (2023) 120: e2221453120

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Protocols for In Vitro Reconstitution of the Cyanobacterial Circadian Clock

Biopolymers (2023): e23559

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Site-Directed Spin Labeling to Elucidating the Mechanism of the Cyanobacterial Circadian Clock

Methods in Enzymology (2022) 666: 59-78

KaiC_by_EM.tiff

Coupling of Distant ATPase Domains in the Circadian Clock Protein KaiC

Nat. Struct. Mol. Biol. (2022) 29: 759-766

A Nighttime Edge Site Intermediate in the Cyanobacterial Circadian Clock Identified by EPR Spectroscopy

JACS (2022) 144:184-194

Reconstitution of an Intact Clock Reveals Mechanisms of Circadian Timekeeping

Science (2021) 374:eabd4453

Commentary in Current Biology (2021) 31:R1532-R1534

Mechanistic Aspects of the Cyanobacterial Circadian Clock

Circadian Rhythms in Bacteria & Microbiomes (2021) pp. 67-77

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Identification and Characterization of Metamorphic Proteins: Current and Future Perspectives

Biopolymers (2021) 112:e23473

A Cyanobacterial Component Required for Pilus Biogenesis Affects the Exoproteome

mBio (2021) 12:e03674-20

Sequence-Based Prediction of Metamorphic Behavior in Proteins

Biophysical J. (2020) 119: 1380-1390

Monitoring Protein-Protein Interactions in the Cyanobacterial Circadian Clock in Real Time via Electron Paramagnetic Resonance Spectroscopy

Biochemistry (2020) 59:2387-2400

An ACS Editor's Choice research article.

Bayesian Modeling Reveals Metabolite‐Dependent Ultrasensitivity in the Cyanobacterial Circadian Clock

Mol Syst Biol (2020)16:e935

Real-Time In Vitro Fluorescence Anisotropy of the Cyanobacterial Circadian Clock

Methods Protoc (2019) 2:42

Structure, Function, and Mechanism of the Core Circadian Clock in Cyanobacteria

J. Biol. Chem. (2018) 293:5026-5034

Genome-Wide Fitness Assessment During Diurnal Growth Reveals an Expanded Role of the Cyanobacterial Circadian Clock Protein KaiA

PNAS (2018) 115:E7174-E7183

Structural Basis of the Day-Night Transition in a Bacterial Circadian Clock

Science (2017) 355:1174-1180

A Protein Fold Switch Joins the Circadian Oscillator to Clock Output in Cyanobacteria

Science (2015) 349:324-328

Cooperative KaiA-KaiB-KaiC Interactions Affect KaiB/SasA Competition in the Circadian Clock of Cyanobacteria

J. Mol. Biol. (2014) 426:389-402

Nuclear Magnetic Resonance Spectroscopy of the Circadian Clock of Cyanobacteria

Integ. Comp. Biol. (2013) 53:93-102

Rhythmic Ring-Ring Stacking Drives the Circadian Oscillator Clockwise

PNAS (2012) 109:16847-16851

Commentary: PNAS (2012) 109:16760-16761

Flexibility of the C-terminal, or CII, Ring of KaiC Governs the Rhythm of the Circadian Clock of Cyanobacteria

PNAS (2011) 108:14431-14436

Commentary: PNAS (2011) 108:14377-14378

The KaiA Protein of the Cyanobacterial Circadian Oscillator is Modulated by a Redox-Active Cofactor

PNAS (2010) 107:5804-5809

Deuterium Isotope Effects on 15N Backbone Chemical Shifts in Proteins

J. Biomol. NMR (2009) 44:119-126

A Novel Allele of kaiA Shortens the Circadian Period and Strengthens Interaction of Oscillator Components in the Cyanobacterium Synechococcus elongatus PCC 7942

J. Bacteriol. (2009) 191:4392-4400

The Day/Night Switch in KaiC, a Central Oscillator Component of the Circadian Clock of Cyanobacteria

PNAS (2008) 105:12825-12830

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Hydrogen-Bonding and pi-pi Base-Stacking Interactions are Coupled in DNA, as Suggested by Calculated and Experimental trans-Hbond Deuterium Isotope Shifts

JACS (2007) 129:11298-11299

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Sensitivity of Hydrogen Bonds of DNA and RNA to Hydration, as Gauged by JNH Measurements in Ethanol–Water Mixtures

J. Biomol. NMR (2007) 37:257-263

NMR Structure of the pseudo-Receiver Domain of CikA

Protein Sci (2007) 16:465-475

Shifting Nanoscopic Clock Gears

Nature Struct. Mol. Biol. (2007) 14:362-363

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Quinone Sensing by the Circadian Input Kinase of the Cyanobacterial Circadian Clock

PNAS (2006) 103:17468-17473

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Computational and Empirical trans-Hydrogen Bond Deuterium Isotope Shifts Suggest that N1–N3 A:U Hydrogen Bonds of RNA are Shorter than those of A:T Hydrogen Bonds of DNA

J. Biomol. NMR (2006) 34:229-236

1JNH Values Show that N1···N3 Hydrogen Bonds are Stronger in dsRNA A:U than dsDNA A:T Base Pairs

JACS (2005) 127:17974-17975

Structure of the N-terminal Domain of the Circadian Clock-Associated Histidine Kinase SasA

J. Mol. Biol. (2004) 342:9-17

Structure of the C-terminal Domain of the Clock Protein KaiA in Complex with a KaiC-Derived Peptide: Implications for KaiC Regulation

PNAS (2004) 101:10925-10930

N1∙∙∙N3 Hydrogen Bonds of A:U Base Pairs of RNA are Stronger than those of A:T Base Pairs of DNA

JACS (2004) 126:5688-5689

Crystal Structure of Circadian Clock Protein KaiA from Synechococcus elongatus

J. Biol. Chem. (2004) 279:20511-20518

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Trans-Hydrogen Bond Deuterium Isotope Effects of A:T base Pairs in DNA

J. Biomol. NMR (2004) 29:65-72

NMR Structure of the KaiC-Interacting C-Terminal Domain of KaiA, a Circadian Clock Protein: Implications for KaiA–KaiC Interaction

PNAS (2004) 101:1479-1484

Observation of a Distinct Transition in the Mode of Interconversion of Ring Pucker Conformers in Non-Crystalline D-Ribose-2′-D from 2H NMR Spin-Alignment

J. Biomol. NMR (2003) 26:249-257

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Deuterium Isotope Effects and Fractionation Factors of Hydrogen-Bonded A:T Base Pairs of DNA

J. Biomol. NMR (2003) 25:105-112

Structure and Function from the Circadian Clock Protein KaiA of Synechococcus elongatus: a Potential Clock Input Mechanism

PNAS (2002) 99:15357-15362

Conformational Heterogeneity in the C-terminal Zinc Fingers of Human MTF-1: an NMR and Zinc-Binding Study

J. Biol. Chem (2001) 276:42322-42332

Conformations of Nucleoside Analogue 1-(2'-Deoxy-β-d-ribofuranosyl)-1,2,4-triazole-3-carboxamide in Different DNA Sequence Contexts

Biochemistry (2001) 40:1518-1527

NMR Structure of a DNA Duplex Containing Nucleoside Analog 1-(2′-deoxy-β-D-ribofuranosyl)-3-nitropyrrole and the Structure of the Unmodified Control

Nucl. Acids Res. (2000) 28:4514-4522

The Solution Structure of the anti-HIV Chemokine vMIP-II

Protein Sci. (1999) 8:2270-2280

Dynamics Study on the Anti-Human Immunodeficiency Virus Chemokine Viral Macrophage-Inflammatory Protein-II (VMIP-II) Reveals a Fully Monomeric Protein

Biochemistry (1999) 38:442-453

Effect of N-Terminal Truncation and Solution Conditions on Chemokine Dimer Stability: Nuclear Magnetic Resonance Structural Analysis of Macrophage Inflammatory Protein 1β Mutants

Biochemistry (1998) 37:9346-9354

Solution NMR Characterization of Hydrogen Bonds in a Protein by Indirect Measurement of Deuterium Quadrupole Couplings

J. Magn. Reson. (1997) 127:54-64

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Equilibrium Protium/Deuterium Fractionation of Backbone Amides in U−13C/15N Labeled Human Ubiquitin by Triple Resonance NMR

JACS (1996) 118:12864-12865

Determination of the Backbone Dihedral Angles φ in Human Ubiquitin from Reparametrized Empirical Karplus Equations

JACS (1996) 118:2483-2494

Reparametrization of the Karplus Relation for 3J(Hα-N) and 3J(HN-C') in Peptides from Uniformly 13C/15N-Enriched Human Ubiquitin

JACS (1995) 117:1810-1813

Sequential Backbone Assignment of Isotopically Enriched Proteins in D2O by Deuterium-Decoupled HA(CA)N and HA(CACO)N

J. Biomol. NMR (1995) 5:376-382

An Efficient Triple-Resonance Experiment for Proton-Directed Sequential Backbone Assignment of Medium-Sized Proteins

J. Magn. Reson. B (1994) 105:196-198

1H, 13C, 15N Nuclear Magnetic Resonance Backbone Assignments and Secondary Structure of Human Calcineurin B

Biochemistry (1994) 33:3540-3547

A Solid-State 2H NMR Investigation of Purine Motion in a 12-Base-Pair RNA Duplex

J. Magn. Reson. B (1994) 105:1-10

Minimizing the Effects of Radio-Frequency Heating in Multidimensional NMR Experiments

J. Biomol. NMR (1993) 3:715-720

Measurement of Three-Bond Nitrogen-Carbon J Couplings in Proteins Uniformly Enriched in 15N and 13C

JACS (1993) 115:5334-5335

Errors in RNA NOESY Distance Measurements in Chimeric and Hybrid Duplexes: Differences in RNA and DNA Proton Relaxation

Biochemistry (1992) 31:3940-3946

A Solid-State 2H NMR Relaxation Study of a 12 Base Pair RNA Duplex

JACS (1992) 114:6583-6585

Considerations in the Application of Orientation-Dependent Analysis of NOE Intensities to DNA Oligonucleotides

J. Magn. Reson. (1992) 100:358-366

High-resolution NMR Studies of Chimeric DNA-RNA-DNA Duplexes, Heteronomous Base Pairing, and Continuous Base Stacking at Junctions

Biochemistry (1991) 30:5248-5257

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