CIRCADIAN CLOCK OF CYANOBACTERIA

Circadian clocks persistently cycle once per day to provide a reliable internal representation of local time under a range of cellular conditions. Our lab is uncovering the mechanisms of this persistence and reliability in the cyanobacterial clock by interrogating the structural, biochemical, biophysical, and thermodynamic aspects of this system. An overview of the LiWang model of the cyanobacterial circadian clock is illustrated here.

WHOLE-CLOCK RECONSTITUTION IN VITRO

Real-time fluorescence.

NMR SPECTROSCOPY OF RECONSTITUTED CLOCK

Atomic-resolution in real time.

CORRELATING UPSTREAM & DOWNSTREAM RHYTHMS

Insights into clock control over gene expression.