CIRCADIAN CLOCK OF CYANOBACTERIA
Circadian clocks persistently cycle once per day to provide a reliable internal representation of local time under a range of cellular conditions. Our lab is uncovering the mechanisms of this persistence and reliability in the cyanobacterial clock by interrogating the structural, biochemical, biophysical, and thermodynamic aspects of this system.
WHOLE-CLOCK RECONSTITUTION IN VITRO
NMR SPECTROSCOPY OF RECONSTITUTED CLOCK
Atomic-resolution in real time.
CORRELATING UPSTREAM & DOWNSTREAM RHYTHMS
Insights into clock control over gene expression.
Our research is supported by the National Institutes of Health and U.S. Army Research Office